期刊
PLOS ONE
卷 9, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0115726
关键词
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资金
- National Institutes of Health [K25CA157940, R01CA90571, R01CA156674, R01GM073981, P01GM081621, R01CA185189, R01GM094388]
- NantWorks, LLC - University of California Discovery Biotechnology Award [Bio07-10663]
- California Institute for Regenerative Medicine Basic Biology 1 Award [RB1-01397]
- Broad Stem Cell Research Center at UCLA
- Caltech-UCLA Joint Center for Translational Medicine
The equal partitioning of cell mass between daughters is the usual and expected outcome of cytokinesis for self-renewing cells. However, most studies of partitioning during cell division have focused on daughter cell shape symmetry or segregation of chromosomes. Here, we use live cell interferometry (LCI) to quantify the partitioning of daughter cell mass during and following cytokinesis. We use adherent and non-adherent mouse fibroblast and mouse and human lymphocyte cell lines as models and show that, on average, mass asymmetries present at the time of cleavage furrow formation persist through cytokinesis. The addition of multiple cytoskeleton-disrupting agents leads to increased asymmetry in mass partitioning which suggests the absence of active mass partitioning mechanisms after cleavage furrow positioning.
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