期刊
PLOS ONE
卷 9, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0113996
关键词
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资金
- Fifth Framework Program of European Commission [QLK4-CT-1999-01288]
- Almeria: Fondo de Investigacion Sanitaria [00/1092E]
- Ankara*: Scientific and Technical Research council of Turkey [SPAG-2237]
- Treatment and Research Foundation of Turkey for Allergy, Asthma and Immunology
- Research Foundation of Hacettepe University Faculty of Medicine
- Athens: the Thorax Foundation Research Centre, Greece
- Cartagena: Fondo de Investigacion Sanitaria [00/1092E]
- Creteil: French Institute of Health and Medical Research (Institut National de la Sante et de la Recherche Medicale (INSERM) [IDS 337/4D001D, 737/69480]
- Ministere de l'Emploi et de la Solidarite [227/7HL02D]
- Mutuelle Generale de l'Education Nationale [257/8PL01F]
- Agence de l'Environnement et de la Maitrise de l'Energie ADEME/PRIMEQUAL 96 [FJ012B]
- Dresden: German Ministry of Education and Research [01 EE 9411-3]
- Hastings: Health Research Council of New Zealand, Asthma and Respiratory Foundation of New Zealand
- Hawkes Bay Medical Research Foundation
- Kintampo*: Linkoping: the Swedish Foundation for Health Care Sciences and Allergy Research
- Madrid: Fondo de Investigacion Sanitaria [00/1092E]
- Mumbai*: Jaslok Hospital & Research Centre
- Munich: German Ministry of Education and Research [01 EE 9411-3]
- Ostersund: the Swedish Foundation for Health Care Sciences and Allergy Research
- Pichincha province: Wellcome Trust
- Porto Alegre: Rudolf und Clothilde Eberhardt Foundation, Ulm, Germany
- Ramallah: Al-Quds University, Directorate General for International Cooperation and Belgian Technical Cooperation
- Riga*
- Rome: Lazio Regional Health Authority
- Tallinn*
- Tbilisi*
- Thessaloniki: the Thorax Foundation Research Centre, Greece
- Tirana*
- Utrecht: Dutch Ministries of the Environment, of Health and of Transport, Rotterdam, the Netherlands
- Valencia: Fondo de Investigacion Sanitaria [00/1092E]
- West Sussex: South Thames National Health Service Regional Research and Development [SPGS 573]
Background: Childhood obesity and asthma are increasing worldwide. A possible link between the two conditions has been postulated. Methods: Cross-sectional studies of stratified random samples of 8-12-year-old children (n=10 652) (16 centres in affluent and 8 centres in non-affluent countries) used the standardized methodology of ISAAC Phase Two. Respiratory and allergic symptoms were ascertained by parental questionnaires. Tests for allergic disease were performed. Height and weight were measured, and overweight and obesity were defined according to international definitions. Prevalence rates and prevalence odds ratios were calculated. Results: Overweight (odds ratio=1.14, 95%-confidence interval: 0.98; 1.33) and obesity (odds ratio=1.67, 95%-confidence interval: 1.25; 2.21) were related to wheeze. The relationship was stronger in affluent than in non-affluent centres. Similar results were found for cough and phlegm, rhinitis and eczema but the associations were mostly driven by children with wheeze. There was a clear association of overweight and obesity with airways obstruction (change in FEV1/FVC, -0.90, 95%-confidence interval: -1.33%; -0.47%, for overweight and -2.46%, 95%-confidence interval: -3.84%; -1.07%, for obesity) whereas the results for the other objective markers, including atopy, were null. Conclusions: Our data from a large international child population confirm that there is a strong relation of body mass index with wheeze especially in affluent countries. Moreover, body mass index is associated with an objective marker of airways obstruction (FEV1/FVC) but no other objective markers of respiratory and allergic disorders.
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