相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Insight into the structural mechanism for PKBα allosteric inhibition by molecular dynamics simulations and free energy calculations
Shi-Feng Chen et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2014)
MoMA-LigPath: a web server to simulate protein-ligand unbinding
Didier Devaurs et al.
NUCLEIC ACIDS RESEARCH (2013)
The PI3K/PKB signaling module as key regulator of hematopoiesis: implications for therapeutic strategies in leukemia
Roel Polak et al.
BLOOD (2012)
MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis
Yan Cheng et al.
MOLECULAR CANCER THERAPEUTICS (2012)
The miRNA-17∼92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation
E. Rao et al.
LEUKEMIA (2012)
Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemia
C. Simioni et al.
LEUKEMIA (2012)
Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to Progestin
Alok Pant et al.
PLOS ONE (2012)
Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes
Shixiong Tan et al.
BIOCHEMICAL JOURNAL (2011)
LigPlot+: Multiple Ligand-Protein Interaction Diagrams for Drug Discovery
Roman A. Laskowski et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2011)
The Akt-Specific Inhibitor MK2206 Selectively Inhibits Thyroid Cancer Cells Harboring Mutations That Can Activate the PI3K/Akt Pathway
Ruixin Liu et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)
First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors
Timothy A. Yap et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Developments in Selective Small Molecule ATP-Competitive Inhibitors Targeting the Serine/Threonine Kinase Akt/PKB
P. Wang et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2011)
Disruption of the AKT Pathway Inhibits Metastasis in an Orthotopic Model of Head and Neck Squamous Cell Carcinoma
Joseph A. Knowles et al.
LARYNGOSCOPE (2011)
Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway
A. M. Martelli et al.
LEUKEMIA (2011)
The PKB/AKT Pathway in Cancer
Amancio Carnero
CURRENT PHARMACEUTICAL DESIGN (2010)
Akt inhibitors in clinical development for the treatment of cancer
Sumanta Kumar Pal et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2010)
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
Hiroshi Hirai et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition
Wen-I Wu et al.
PLOS ONE (2010)
Jalview Version 2-a multiple sequence alignment editor and analysis workbench
Andrew M. Waterhouse et al.
BIOINFORMATICS (2009)
A Spectroscopic Investigation into the Interactions of 3′-O-Carboxy Esters of Thymidine with Bovine Serum Albumin
Kalyan Sundar Ghosh et al.
BIOPOLYMERS (2009)
Targeting the phosphoinositide 3-kinase pathway in cancer
Pixu Liu et al.
NATURE REVIEWS DRUG DISCOVERY (2009)
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
Charlotte J. Green et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module
Natarajan Kannan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Cisplatin induces PKB/Akt activation and p38MAPK phosphorylation of the EGF receptor
S. E. Winograd-Katz et al.
ONCOGENE (2006)
A path planning approach for computing large-amplitude motions of flexible molecules
J Cortés et al.
BIOINFORMATICS (2005)
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
CW Lindsley et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
SF Barnett et al.
BIOCHEMICAL JOURNAL (2005)
The Jalview Java alignment editor
M Clamp et al.
BIOINFORMATICS (2004)
Advances in protein kinase B signalling:: AKTion on multiple fronts
DP Brazil et al.
TRENDS IN BIOCHEMICAL SCIENCES (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Comparative evaluation of 11 scoring functions for molecular docking
RX Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Molecular mechanism for the regulation of protein kinase B/Akt by hydrophobic motif phosphorylation
J Yang et al.
MOLECULAR CELL (2002)
Further development and validation of empirical scoring functions for structure-based binding affinity prediction
RX Wang et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2002)
DOCK 4.0: Search strategies for automated molecular docking of flexible molecule databases
TJA Ewing et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2001)