期刊
PLOS ONE
卷 9, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0110731
关键词
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资金
- ARCHE Collaborative Research Grant from the Foundation for AIDS Research [amFAR 108165-50-RGRL]
- Martin Delaney CARE and DARE Collaboratories (NIH) [AI096113, 1U19AI096109]
- NIH [43222]
- Howard Hughes Medical Institute
- Department of Veterans Affairs
- James Pendleton Charitable Trust
- National Institutes of Health [AI080193, AI74621, AI69432-S]
- CFAR [AI306214]
- Department of Veterans Affairs (VA Career Development Award) [1 IK2 CX000520-01]
- NIAID [RO1AIO87145, K24AIO69994]
- UCSF/Gladstone CFAR [P30 AIO27763]
- UCSF Clinical and Translational Research Institute Clinical Research Center [UL 1 RR024131]
- Center for AIDS Prevention Studies [P30 MH62246]
The association between the host immune environment and the size of the HIV reservoir during effective antiretroviral therapy is not clear. Progress has also been limited by the lack of a well-accepted assay for quantifying HIV during therapy. We examined the association between multiple measurements of HIV and T cell activation (as defined by markers including CD38, HLA-DR, CCR5 and PD-1) in 30 antiretroviral-treated HIV-infected adults. We found a consistent association between the frequency of CD4(+) and CD8(+) T cells expressing HLA-DR and the frequency of resting CD4(+) T cells containing HIV DNA. This study highlights the need to further examine this relationship and to better characterize the biology of markers commonly used in HIV studies. These results may also have implications for reactivation strategies.
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