相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
Gregg L. Semenza
Annual Review of Pathology-Mechanisms of Disease (2013)
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
Noel A. Warfel et al.
CELL CYCLE (2013)
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
Lucas B. Sullivan et al.
MOLECULAR CELL (2013)
Resetting glutamine-dependent metabolism and oxygen consumption
Tsung-Chin Lin et al.
AUTOPHAGY (2012)
Hypoxia-Inducible Factors in Physiology and Medicine
Gregg L. Semenza
CELL (2012)
Role of reactive oxygen species in the regulation of HIF-1 by prolyl hydroxylase 2 under mild hypoxia
Helene Niecknig et al.
FREE RADICAL RESEARCH (2012)
Alpha-ketoglutarate (AKG) inhibits proliferation of colon adenocarcinoma cells in normoxic conditions
Wojciech Rzeski et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2012)
Prolyl-4-hydroxylase PHD2-and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis
M. R. Bordoli et al.
ONCOGENE (2011)
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
Na Zhang et al.
CELL METABOLISM (2010)
Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α
Weibo Luo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
G. L. Semenza
ONCOGENE (2010)
PIASy stimulates HIF1α SUMOylation and negatively regulates HIF1α activity in response to hypoxia
X. Kang et al.
ONCOGENE (2010)
Reactivating HIF prolyl hydroxylases under hypoxia results in metabolic catastrophe and cell death
D. A. Tennant et al.
ONCOGENE (2009)
The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans
Yi Zhang et al.
PLOS ONE (2009)
Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1α
Shimin Zhao et al.
SCIENCE (2009)
Novel Roles for Protein Kinase Cδ-dependent Signaling Pathways in Acute Hypoxic Stress-induced Autophagy
Jo-Lin Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
William G. Kaelin et al.
MOLECULAR CELL (2008)
Expanding chemical biology of 2-oxoglutarate oxygenases
Christoph Loenarz et al.
NATURE CHEMICAL BIOLOGY (2008)
Role for KAP1 serine 824 phosphorylation and sumoylation/desumoylation switch in regulating KAP1-mediated transcriptional repression
Xu Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
SUMO-Specific protease 1 is essential for stabilization of HIF1α during hypoxia
Jinke Cheng et al.
CELL (2007)
Protein kinase Cδ-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent
Carlos Clavijo et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2007)
Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells
Elaine D. MacKenzie et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1α and mediates its destabilization in a VHL-independent manner
Daniela Fluegel et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Doxorubicin down-regulates Kruppel-associated box domain-associated protein 1 sumoylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells
Yung-Kang Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Hypoxia-induced resistance to cisplatin and doxorubicin in non-small cell lung cancer is inhibited by silencing of HIF-1α gene
Xianrang Song et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
Role of hypoxia-inducible factor (HIF)-1α-versus HIF-2α in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-1, or loss of von Hippel-Lindau function:: Implications for targeting the HIF pathway
Veronica A. Carroll et al.
CANCER RESEARCH (2006)
Antianglogenic potential of the mammalian target of rapamycin inhibitor temsirolimus
Donatella Del Bufalo et al.
CANCER RESEARCH (2006)
Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity:: Assessment of an oral agent that stimulates erythropoietin production
M Safran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1α
DA Chan et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
JS Isaacs et al.
CANCER CELL (2005)
Effect of low glutamine/glucose on hypoxia-induced elevation of hypoxia-inducible factor-1α in human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells
SJ Kwon et al.
CLINICAL CANCER RESEARCH (2005)
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
RD Guzy et al.
CELL METABOLISM (2005)
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase
MA Selak et al.
CANCER CELL (2005)
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
RJ Appelhoff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
HIF-1α induces cell cycle arrest by functionally counteracting Myc
M Koshiji et al.
EMBO JOURNAL (2004)
Oxygen sensing by HIF hydroxylases
CJ Schofield et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
E Berra et al.
EMBO JOURNAL (2003)
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis
CW Pugh et al.
SEMINARS IN CANCER BIOLOGY (2003)
Regulation and destabilization of HIF-1α by ARD1-mediated acetylation
JW Jeong et al.
CELL (2002)
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
K Kondo et al.
CANCER CELL (2002)
FIH-1:: a novel protein that interacts with HIF-1α and VHL to mediate repression of HIF-1 transcriptional activity
PC Mahon et al.
GENES & DEVELOPMENT (2001)
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
ACR Epstein et al.
CELL (2001)
Tissue microarray (TMA) technology:: miniaturized pathology archives for high-throughput in situ studies
L Bubendorf et al.
JOURNAL OF PATHOLOGY (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)