期刊
PLOS ONE
卷 9, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0113637
关键词
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资金
- Wellcome Trust Fellowship [WT099055AIA]
- UK Medical Research Council [MC_UU_12019/4, MC_UU_12013/5, MC_UU_12013/9, G0500997]
- AXA Research Fund
- University of Essex
- ESRC
- Wellcome Trust [092731]
- National Institute on Aging [2RO1AG7644-01A1, 2RO1AG017644]
- consortium of UK government departments
- Arthritis Research United Kingdom
- University of Southampton
- Biotechnology and Biological Sciences Research Council
- Royal Society-Wolfson Research Merit Award
- Scottish Government's Chief Scientist Office
- Age UK (Disconnected Mind project)
- Medical Research Council
- Dunhill Medical Trust [R124/0509]
- Newcastle Healthcare Charity
- National Institute for Health Research Newcastle Biomedical Research Centre, based at Newcastle upon Tyne Hospitals NHS Foundation Trust
- Newcastle University
- Dunhill Medical Trust
- Arthritis Research UK
- UK Food Standards Agency
- Economic and Social Research Council (ESRC)
- ESRC [ES/K005146/1] Funding Source: UKRI
- MRC [MC_UU_12013/5, G0500997, MC_UP_A620_1015, G0700704, MC_UU_12017/5, MC_UU_12019/4, MC_UU_12011/2, MC_UU_12013/9, MC_UU_12019/1, MR/J50001X/1] Funding Source: UKRI
- Chief Scientist Office [SPHSU2] Funding Source: researchfish
- Economic and Social Research Council [ES/K005146/1] Funding Source: researchfish
- Medical Research Council [G0700704, U1475000002, MR/J50001X/1, MC_UU_12011/2, MC_UP_A620_1015, MC_UU_12019/4, MC_UU_12013/9, MR/K026992/1, MC_UU_12013/5, MC_PC_15018, MC_UU_12019/1, G0500997, MC_UU_12017/5] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10260] Funding Source: researchfish
Introduction: Epidemiological studies have shown that weaker grip strength in later life is associated with disability, morbidity, and mortality. Grip strength is a key component of the sarcopenia and frailty phenotypes and yet it is unclear how individual measurements should be interpreted. Our objective was to produce cross-sectional centile values for grip strength across the life course. A secondary objective was to examine the impact of different aspects of measurement protocol. Methods: We combined 60,803 observations from 49,964 participants (26,687 female) of 12 general population studies in Great Britain. We produced centile curves for ages 4 to 90 and investigated the prevalence of weak grip, defined as strength at least 2.5 SDs below the gender-specific peak mean. We carried out a series of sensitivity analyses to assess the impact of dynamometer type and measurement position (seated or standing). Results: Our results suggested three overall periods: an increase to peak in early adult life, maintenance through to midlife, and decline from midlife onwards. Males were on average stronger than females from adolescence onwards: males' peak median grip was 51 kg between ages 29 and 39, compared to 31 kg in females between ages 26 and 42. Weak grip strength, defined as strength at least 2.5 SDs below the gender-specific peak mean, increased sharply with age, reaching a prevalence of 23% in males and 27% in females by age 80. Sensitivity analyses suggested our findings were robust to differences in dynamometer type and measurement position. Conclusion: This is the first study to provide normative data for grip strength across the life course. These centile values have the potential to inform the clinical assessment of grip strength which is recognised as an important part of the identification of people with sarcopenia and frailty.
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