期刊
PLOS ONE
卷 9, 期 8, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0103841
关键词
-
资金
- national natural science foundation of China [81100623]
- Beijing Natural Science Foundation [7121012]
Background: Bone formation marker procollagen I N-terminal peptide (PINP) and resorption marker C-terminal telopeptide of type I collagen (beta-CTX) are useful biomarkers for differential diagnosis and therapeutic evaluation of osteoporosis, but reference values are required. Methods: The multi-center, cross-sectional Chinese Bone Turnover Marker Study included 3800 healthy volunteers in 5 Chinese cities. Serum PINP, beta-CTX, parathyroid hormone (PTH) and 25OHD levels were measured by chemiluminescence assay. Lumbar spine and proximal femur BMD were measured by dual-energy X-ray absorptiometry. Serum PINP and beta-CTX levels were assessed by age, gender, weight, recruitment latitude, levels of PTH and 25OHD. Results: Subjects (n = 1436, M:F, 500:936; mean age 50.6 +/- 19.6 years) exhibited non-normally distributed PINP and beta-CTX peaking between 15-19 years, gradually declining throughout adulthood, elevating within 10 years of postmenopause, and then declining by age 70. In women between the age of 30 and menopause, median PINP and beta-CTX levels were 40.42 (95% CI: 17.10-102.15) and 0.26 (95% CI: 0.08-0.72) ng/mL, respectively. beta-CTX and PINP were positively linearly correlated (r = 0.599, P < 0.001). beta-CTX correlated positively (r = 0.054 and 0.093) and PINP correlated negatively (r = -0.012 and -0.053) with 25OHD and PTH (P < 0.05). Conclusions: We established Chinese reference ranges for PINP and CTX. Chinese individuals exhibited high serum PINP and beta-CTX levels between 15 and 19 years of age and at menopause, which gradually declined after 70 years of age.
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