4.6 Article

MicroRNA-31 Is Overexpressed in Cutaneous Squamous Cell Carcinoma and Regulates Cell Motility and Colony Formation Ability of Tumor Cells

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PLOS ONE
卷 9, 期 7, 页码 -

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PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0103206

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资金

  1. Swedish Research Council (Vetenskapsradet), Cancerfonden [CAN 2012/730]
  2. Swedish Society of Medicine (Svenska Lakaresallskapet)
  3. Swedish Psoriasis Association (Psoriasisforbundet)
  4. European Skin Research Foundation
  5. Welander and Finsens Foundation
  6. Tore Nilssons Foundation
  7. Lars Hierta Memorial Foundation
  8. Sigurt and Elsa Golje Memorial Foundation
  9. Centre of Excellence for Research on Inflammation and Cardiovascular Disease
  10. Karolinska Institute
  11. Stockholm County Council
  12. Swedish Society for Medical Research
  13. LEO Pharma Research Foundation

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Cutaneous squamous cell carcinoma (cSCC) is a malignancy of epidermal keratinocytes that is responsible for approximately 20% of skin cancer-related death yearly. We have previously compared the microRNA (miRNA) expression profile of cSCC to healthy skin and found the dysregulation of miRNAs in human cSCC. In this study we show that miR-31 is overexpressed in cSCC (n = 68) compared to healthy skin (n = 34) and precancerous skin lesions (actinic keratosis, n = 12). LNA in situ hybridization revealed that miR-31 was specifically up-regulated in tumor cells. Mechanistic studies of inhibition of endogenous miR-31 in human metastatic cSCC cells revealed suppressed migration, invasion and colony forming ability, whereas overexpression of miR-31 induced these phenotypes. These results indicate that miR-31 regulates cancer-associated phenotypes of cSCC and identify miR-31 as a potential target for cSCC treatment.

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