期刊
PLOS ONE
卷 9, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0101999
关键词
-
资金
- Marie Curie Initial Training Network ARIADNE [FP7-PEOPLE-ITN-237936]
- Spanish Ministerio de Economia y Competitividad (MINECO) [BIO2010-15505]
- Wellcome Trust [080088, 086827, 075470, 099215]
- Wellcome Trust Strategic Award [097377]
- FP7 [HEALTH-F2- 2010-260338-ALLFUN]
- Chief Scientist Senior Clinical Fellowship
- Chief Scientist Office [SCD/03] Funding Source: researchfish
Fusarium oxysporum is an important plant pathogen and an opportunistic pathogen of humans. Here we investigated phagocytosis of F. oxysporum by J774.1 murine cell line macrophages using live cell video microscopy. Macrophages avidly migrated towards F. oxysporum germlings and were rapidly engulfed after cell-cell contact was established. F. oxysporum germlings continued hyphal growth after engulfment by macrophages, leading to associated macrophage lysis and escape. Macrophage killing depended on the multiplicity of infection. After engulfment, F. oxysporum inhibited macrophages from completing mitosis, resulting in large daughter cells fused together by means of a F. oxysporum hypha. These results shed new light on the initial stages of Fusarium infection and the innate immune response of the mammalian host.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据