期刊
PLOS ONE
卷 9, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0101363
关键词
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资金
- U.S. National Science Foundation [DMS-1120824]
- China National Science Foundation [31271408]
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1120824] Funding Source: National Science Foundation
Intron-containing and intronless genes have different biological properties and statistical characteristics. Here we propose a new computational method to distinguish between intron-containing and intronless gene sequences. Seven feature parameters alpha, beta, gamma, lambda, theta, phi, and sigma based on detrended fluctuation analysis (DFA) are fully used, and thus we can compute a 7-dimensional feature vector for any given gene sequence to be discriminated. Furthermore, support vector machine (SVM) classifier with Gaussian radial basis kernel function is performed on this feature space to classify the genes into intron-containing and intronless. We investigate the performance of the proposed method in comparison with other state-of-the-art algorithms on biological datasets. The experimental results show that our new method significantly improves the accuracy over those existing techniques.
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