期刊
ARTHRITIS CARE & RESEARCH
卷 67, 期 5, 页码 640-650出版社
WILEY
DOI: 10.1002/acr.22504
关键词
-
类别
资金
- Oak Foundation
- Velux Foundation
- Cambridge Weight Plan (UK)
- Danish Rheumatism Association
- Augustinus Fonden
- A.P. Moller Foundation for the Advancement of Medical Science
- Aase og Ejnar Danielsens Fond
- Bjarne Jensens Fond
- Horslev Fonden
- Cambridge Manufacturing Company
- Opus
- New Nordic Diet
- Cambridge Weight Plan
- Servier
- Ossur
- Teijin
- AbbVie
- Medivir
- Flexion
- Arena Pharmaceuticals
- BioCare
- Boehringer Ingelheim Pharma
- Dutch Beer Knowledge Institute
- Gelesis
- Global Dairy Platform
- MacDonald's
- McCain Foods
- Novo Nordisk
- Orexigen Therapeutics
- Pathway Genomics
- Pfizer
- Psyadon Pharmaceuticals
- Rhythm Pharmaceuticals
- S-Biotek
- Twinlab
- Vivus
Objective. To compare results of obese patients with knee osteoarthritis (OA) who, after an intensive weight loss regimen, received 1 year of either dietary support (D), a knee-exercise program (E), or no attention (C; control group). Methods. We conducted a randomized, 2-phase, parallel-group trial. A total of 192 obese participants with knee OA were enrolled; the mean age was 62.5 years and 81% were women with a mean entry weight of 103.2 kg. In phase 1, all participants were randomly assigned to 1 of 3 groups and began a dietary regimen of 400-810 and 1,250 kcal/day for 16 weeks (2 8-week phases) to achieve a major weight loss. Phase 2 consisted of 52 weeks' maintenance in either group D, E, or C. Outcomes were changes from randomization in pain on a 100-mm visual analog scale, weight, and response according to the Outcome Measures in Rheumatology-Osteoarthritis Research Society International criteria. Results. Mean weight loss for phase 1 was 12.8 kg. After 1 year on maintenance therapy, the D group sustained a lower weight (11.0 kg, 95% confidence interval [95% CI] 9.0, 12.8 kg) than those in the E (6.2, 95% CI 4.4, 8.1 kg) and C (8.2, 95% CI 6.4, 10.1 kg) groups (P = 0.002 by analysis of covariance [ANCOVA]). Adherence was low in the E group. All groups had statistically significant pain reduction (D: 6.1; E: 5.6; and C: 5.5 mm) with no difference between groups (P = 0.98 by ANCOVA). In each group 32 (50%), 26 (41%), and 33 (52%) participants responded to treatment in the D, E, and C groups, respectively, with no statistically significant difference in the number of responders (P = 0.41). Conclusion. A significant weight reduction with a 1-year maintenance program improves knee OA symptoms irrespective of maintenance program.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据