期刊
PLOS ONE
卷 9, 期 6, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0098781
关键词
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资金
- Terman Fellowship
- Baxter Foundation
- Coulter Foundation
- Spectrum Foundation [NIH CTSA UL1 TR000093]
- C-Idea (National Institutes of Health) [RC4 TW008781-01]
- Bill and Melinda Gates Foundation
- Pew Foundation
- Gordon and Betty Moore foundation
- NIH Fogarty Institute Global Health Equity Scholars (GHES) Fellowship
- NSF
Here we describe an ultra-low-cost origami-based approach for large-scale manufacturing of microscopes, specifically demonstrating brightfield, darkfield, and fluorescence microscopes. Merging principles of optical design with origami enables high-volume fabrication of microscopes from 2D media. Flexure mechanisms created via folding enable a flat compact design. Structural loops in folded paper provide kinematic constraints as a means for passive self-alignment. This light, rugged instrument can survive harsh field conditions while providing a diversity of imaging capabilities, thus serving wide-ranging applications for cost-effective, portable microscopes in science and education.
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