期刊
PLOS ONE
卷 9, 期 6, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0097794
关键词
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资金
- Ministry of Science and Technology of China [2008ZX10002-007, 2008ZX10002-018, 2008ZX10002-025]
- Leading Talents of Science in Shanghai [022]
- Key Discipline Construction of Evidence-Based Public Health in Shanghai [12GWZX0602]
- National Science Foundation of China [81373105, 81088001, 81372122]
- Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8]
Background: Decreased P300 amplitude is one of the most consistent findings in patients with schizophrenia. However, whether prolonged P300 latency occurs in patients with schizophrenia, especially first-episode schizophrenia (FES) patients, remains controversial. Methods: A meta-analyses of P300 aberration in FES patients and healthy control(HC) group was conducted. The meta-regression analysis was performed using a random effects model. The pooled standardized effect size (PSES) was calculated as the division of the difference between the means of the two groups by the common standard deviation. Results: A total of 569 FES patients and 747 HCs were included in this meta-analysis. P300 amplitude was significantly reduced (PSES = 20.83, 95% CI: 21.02-0.65, P = 0.00001) and P300 latency was delayed significantly in FES patients (PSES = 20.48, 95% CI: 0.14-0.81, P = 0.005). The meta-regression analysis showed that task difficulty was a source of heterogeneity. Conclusions: The meta-analysis confirms that disrupted information processing is found in FES patients, which is manifested by smaller P300 amplitude and delayed P300 latency.
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