期刊
PLOS ONE
卷 9, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0089596
关键词
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资金
- European Regional Development Fond (ERDF) of the European Union
- Ministerium fur Innovation, Wissenschaft und Forschung des Landes Nordrhein-Westfalen (ParkChip) [FZ 280381102]
- Creating the Center of Excellence at the University of Szeged [TAMOP-4.2.1./B-09/1/KONV-2010-0005]
- European Union
- European Regional Development Fund
Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections of IgG from ALS patients into mice are known to specifically mark motor neurons. Moreover, IgG has been found in upper and lower motor neurons in ALS patients. These results led us to perform a case-control study using human protein microarrays to identify the antibody profiles of serum samples from 20 ALS patients and 20 healthy controls. We demonstrated high levels of 20 IgG antibodies that distinguished the patients from the controls. These findings suggest that a panel of antibodies may serve as a potential diagnostic biomarker for ALS.
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