期刊
VIRUSES-BASEL
卷 7, 期 11, 页码 5902-5907出版社
MDPI AG
DOI: 10.3390/v7112917
关键词
Chikungunya virus; Aedes albopictus; salivary glands; budding; replication; transmission electron microscopy
类别
资金
- Institut Pasteur, the French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases [ANR-10-LABX-62-IBEID]
- French Ministry of Superior Education and Research
Chikungunya virus (CHIKV) is an emerging arbovirus transmitted to humans by mosquitoes such as Aedes albopictus. To be transmitted, CHIKV must replicate in the mosquito midgut, then disseminate in the hemocele and infect the salivary glands before being released in saliva. We have developed a standardized protocol to visualize viral particles in the mosquito salivary glands using transmission electron microscopy. Here we provide direct evidence for CHIKV replication and storage in Ae. albopictus salivary glands.
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