期刊
VIRUSES-BASEL
卷 7, 期 11, 页码 6051-6066出版社
MDPI
DOI: 10.3390/v7112920
关键词
enterovirus; central nervous system; neurotropism; pathogenesis
类别
资金
- [CMRPD 1D0311-3]
- [CMRPD 1E0401-3]
- [MOST 104-2320-B-182-024-MY3]
- [CMRPD 1C0601-3]
- [CMRPD 190251-3]
Enteroviruses are a group of positive-sense single stranded viruses that belong to the Picornaviridae family. Most enteroviruses infect humans from the gastrointestinal tract and cause mild symptoms. However, several enteroviruses can invade the central nervous system (CNS) and result in various neurological symptoms that are correlated to mortality associated with enteroviral infections. In recent years, large outbreaks of enteroviruses occurred worldwide. Therefore, these neurotropic enteroviruses have been deemed as re-emerging pathogens. Although these viruses are becoming large threats to public health, our understanding of these viruses, especially for non-polio enteroviruses, is limited. In this article, we review recent advances in the trafficking of these pathogens from the peripheral to the central nervous system, compare their cell tropism, and discuss the effects of viral infections in their host neuronal cells.
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