期刊
VIRUSES-BASEL
卷 8, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v8010006
关键词
entry inhibitor; hemagglutinin; quercetin; influenza A virus
类别
资金
- Pearl River S & T Nova program of Guangzhou [2014J2200033]
- Natural Science Foundation of China [U1301224]
- Shanghai Joint Research Projects on the Prevention and Control of Avian Influenza H7N9 Virus [2013QLG010]
Influenza A viruses (IAVs) cause seasonal pandemics and epidemics with high morbidity and mortality, which calls for effective anti-IAV agents. The glycoprotein hemagglutinin of influenza virus plays a crucial role in the initial stage of virus infection, making it a potential target for anti-influenza therapeutics development. Here we found that quercetin inhibited influenza infection with a wide spectrum of strains, including A/Puerto Rico/8/34 (H1N1), A/FM-1/47/1 (H1N1), and A/Aichi/2/68 (H3N2) with half maximal inhibitory concentration (IC50) of 7.756 +/- 1.097, 6.225 +/- 0.467, and 2.738 +/- 1.931 mu g/mL, respectively. Mechanism studies identified that quercetin showed interaction with the HA2 subunit. Moreover, quercetin could inhibit the entry of the H5N1 virus using the pseudovirus-based drug screening system. This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of IAV infections.
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