期刊
PLOS ONE
卷 9, 期 3, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0092122
关键词
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资金
- Conference Episcopale Italienne (CEI)
- Union Economique Monetaire Ouest Africaine (UEMOA)
- Fondation BNP-Paris
- Region Auvergne
- Fond Europeen de Developpement Regional (FEDER)
- Association de Recherche sur les Tumeurs Prostatiques (ARTP)
- Fondation ARC
- Ligue contre le Cancer
This research highlights the chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils from leaves of Ocimum basilicum, Ocimum americanum, Hyptis spicigera, Lippia multiflora, Ageratum conyzoides, Eucalyptus camaldulensis and Zingiber officinale. Essential oils were analyzed by gas chromatography-mass spectrometry and gas chromatography-flame ionization detector. Major constituents were alpha-terpineol (59.78%) and beta-caryophyllene (10.54%) for Ocimum basilicum; 1, 8-cineol (31.22%), camphor (12.730%), alpha-pinene (6.87%) and trans alpha-bergamotene (5.32%) for Ocimum americanum; beta-caryophyllene (21%), alpha-pinene (20.11%), sabinene (10.26%), beta-pinene (9.22%) and alpha-phellandrene (7.03%) for Hyptis spicigera; p-cymene (25.27%), beta-caryophyllene (12.70%), thymol (11.88), gamma-terpinene (9.17%) and thymyle acetate (7.64%) for Lippia multiflora; precocene (82.10%) for Ageratum conyzoides; eucalyptol (59.55%), a-pinene (9.17%) and limonene (8.76%) for Eucalyptus camaldulensis; arcurcumene (16.67%), camphene (12.70%), zingiberene (8.40%), beta-bisabolene (7.83%) and beta-sesquiphellandrene (5.34%) for Zingiber officinale. Antioxidant activities were examined using 1,1-diphenyl-2-picryl-hydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. O. basilicum and L. multiflora exhibited the highest antioxidant activity in DPPH and ABTS tests, respectively. Anti-inflammatory properties were evaluated by measuring the inhibition of lipoxygenase activity and essential oil of Z. officinale was the most active. Anti-proliferative effect was assayed by the measurement of MTT on LNCaP and PC-3 prostate cancer cell lines, and SF-763 and SF-767 glioblastoma cell lines. Essential oils from A. conyzoides and L. multiflora were the most active on LNCaP and PC-3 cell lines, respectively. The SF-767 glioblastoma cell line was the most sensitive to O. basilicum and L. multiflora EOs while essential oil of A. conyzoides showed the highest activity on SF-763 cells. Altogether these results justify the use of these plants in traditional medicine in Burkina Faso and open a new field of investigation in the characterization of the molecules involved in anti-proliferative processes.
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