期刊
VIRUSES-BASEL
卷 7, 期 10, 页码 5319-5327出版社
MDPI AG
DOI: 10.3390/v7102873
关键词
influenza virus; reporter virus; multi-modal imaging; multiplicity reactivation
类别
资金
- National Institute of General Medical Sciences, [R00GM088484]
- Shaw Scientist Award
- American Lung Association Basic Research Grant [RG-310016]
- NIH National Research Service Award [T32 GM07215]
Reporter viruses are useful probes for studying multiple stages of the viral life cycle. Here we describe an expanded toolbox of fluorescent and bioluminescent influenza A reporter viruses. The enhanced utility of these tools enabled kinetic studies of viral attachment, infection, and co-infection. Multi-modal bioluminescence and positron emission tomography-computed tomography (PET/CT) imaging of infected animals revealed that antiviral treatment reduced viral load, dissemination, and inflammation. These new technologies and applications will dramatically accelerate in vitro and in vivo influenza virus studies.
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