期刊
PLOS ONE
卷 8, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0084091
关键词
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资金
- California HIV Research Program grant [D09-SF-313]
- National Institutes of Health (NIH) [T32 AI060530, 2T32AI007641]
- Gates Foundation [OPP1024421]
- NIH [U01 AI43641, R37 AI40312]
- Human Frontier Science Program
- National Institute of Arthritis and Musculoskeletal and Skin Diseases Academic Rheumatology Training Grant
- Rosalind Russell Arthritis Center
- National Institutes of Health Director's Pioneer Award as part of the National Institutes of Health Roadmap for Medical Research [DPI OD00329]
- Centers for AIDS Research at UCSF [PO AI27763]
- CFAR Network of Integrated Systems [R24 AI067039]
- UCSF CTSI [UL1 RR024131]
- National Institute of Allergy and Infectious Diseases [R01 AI087145, K24AI069994, AI-76174]
- AIDS Research Institute at UCSF
- Harvey V. Berneking Living Trust
- Bill and Melinda Gates Foundation [OPP1024421] Funding Source: Bill and Melinda Gates Foundation
HIV-mediated immune dysfunction may influence CD4(+) T cell recovery during suppressive antiretroviral therapy (ART). We analyzed cellular biomarkers of immunological inflammation, maturation, and senescence in HIV-infected subjects on early suppressive ART. We performed longitudinal analyses of peripheral immunological biomarkers of subjects on suppressive ART (n = 24) from early treatment (median 6.4 months, interquartile range [IQR] 4.8-13.9 months) to 1-2 years of follow-up (median 19.8 months, IQR 18.3-24.6 months). We performed multivariate regression to determine which biomarkers were associated with and/or predictive of CD4(+) T cell recovery. After adjusting for the pre-ART CD4(+) T cell count, age, proximal CD4(+) T cell count, and length of ART medication, the percentage of CD27(+)CD8(+) T cells remained significantly associated with the CD4(+) T cell recovery rate (beta = 0.092 cells/ul/month, P = 0.028). In HIV-infected subjects starting suppressive ART, patients with the highest percentage of CD8(+) T cells expressing CD27 had the greatest rate of CD4(+) T cell recovery.
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