期刊
VIRUSES-BASEL
卷 7, 期 8, 页码 4624-4639出版社
MDPI
DOI: 10.3390/v7082836
关键词
mosquito; Aedes; arbovirus; dengue; chikungunya; ROS
类别
资金
- Wellcome Trust [WT095121]
- BBSRC [BB/H016511/1]
- BBSRC [BB/H016511/1] Funding Source: UKRI
Aedes albopictus is a major vector of dengue (DENV) and chikungunya (CHIKV) viruses, causing millions of infections annually. It naturally carries, at high frequency, the intracellular inherited bacterial endosymbiont Wolbachia strains wAlbA and wAlbB; transinfection with the higher-density Wolbachia strain wMel from Drosophila melanogaster led to transmission blocking of both arboviruses. The hypothesis that reactive oxygen species (ROS)-induced immune activation plays a role in arbovirus inhibition in this species was examined. In contrast to previous observations in Ae. aegypti, elevation of ROS levels was not observed in either cell lines or mosquito lines carrying the wild-type Wolbachia or higher-density DrosophilaWolbachia strains. There was also no upregulation of genes controlling innate immune pathways or with antioxidant/ROS-producing functions. These data suggest that ROS-mediated immune activation is not an important component of the viral transmission-blocking phenotype in this species.
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