期刊
PLOS ONE
卷 8, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0081142
关键词
-
资金
- Danish Council for Independent Research - Medical Sciences [22-04-0404]
- Danida through the Consultative Research Committee for Development Research [104.Dan.8-898]
Background: Little is known about vitamin D status in low-income populations burdened with infectious diseases. Hence, there is a need for data on correlates of serum 25-hydroxy vitamin D (S-25(OH)D) and its validity during infections. Objective: To assess the role of pulmonary TB (PTB) and HIV as correlates of S-25(OH)D. Design: Age-sex-matched cross-sectional study among PTB patients and non-TB controls. Methods: PTB patients were categorized as sputum negative (PTB-) and positive (PTB+) by culture. Non-TB controls were randomly selected among age-sex-matched neighbours to PTB+ patients. Height, weight, arm circumference and triceps skinfold were measured, and body mass index (BMI), arm fat (AFA) and muscle area (AMA) computed. HIV status, and S-25(OH)D, C-reactive protein (S-CRP) and alpha(1)-acid glycoprotein (S-AGP) were determined. Linear regression analysis with controls and PTB patients combined was used to identify correlates of S-25(OH)D. Results: S-25(OH)D data were available on 97.8% (1570) of 1605 participants. Mean (SD) S-25(OH)D was 84.4 (25.6) nmol/L with 39.6% <75 nmol/L among 347 non-TB controls. Time of recruitment, sex, PTB and HIV, and elevated S-AGP were correlates of S-25(OH)D. S-25(OH)D was 24.8 (95% CI 18.6; 30.9) nmol/L higher in PTB compared to controls among females, but only 9.8 (95% CI: 4.5; 15.2) nmol/L among males (interaction p<0.0001). Females had 13.8 (95% CI: 8.2; 21.9) nmol/L lower S-25(OH)D than males, and HIV infected individuals had 8.5 (95% CI: 4.9; 12.1) higher S-25(OH)D compared to uninfected. Elevated S-AGP was a positive correlate of S-25(OH)D. Low BMI was associated with S-25(OH)D, but not with infections or SAGP in the model. Conclusion: While S-25(OH)D may decline transiently during a mild acute phase response, it may increase if the acute phase response leads to loss of fat. The validity of S-25(OH)D as a marker of vitamin D status may be affected by infections.
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