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Stefan Rose-John
PHARMACOLOGICAL RESEARCH (2013)
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TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals
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JOURNAL OF CELL BIOLOGY (2012)
Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE
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iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS
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SCIENCE (2012)
Pro- and anti-apoptotic CD95 signaling in T cells
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CELL COMMUNICATION AND SIGNALING (2011)
Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells
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CELL COMMUNICATION AND SIGNALING (2011)
The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9
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CELLULAR AND MOLECULAR LIFE SCIENCES (2011)
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling
Silvio Weber et al.
DEVELOPMENT (2011)
Insights into the molecular regulation of FasL (CD178) biology
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EUROPEAN JOURNAL OF CELL BIOLOGY (2011)
The A Disintegrin And Metalloproteases ADAM10 and ADAM17: Novel drug targets with therapeutic potential?
Paul Saftig et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2011)
ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein
Marcia L. Moss et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17
Ahmad Trad et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2011)
Effector Granules in Human T Lymphocytes: Proteomic Evidence for Two Distinct Species of Cytotoxic Effector Vesicles
Hendrik Schmidt et al.
JOURNAL OF PROTEOME RESEARCH (2011)
PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways
Marie Kveiborg et al.
PLOS ONE (2011)
TACE/ADAM-17 Phosphorylation by PKC-Epsilon Mediates Premalignant Changes in Tobacco Smoke-Exposed Lung Cells
Hassan Lemjabbar-Alaoui et al.
PLOS ONE (2011)
ADAM17: a molecular switch to control inflammation and tissue regeneration
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ADAM-17 Is Activated by the Mitogenic Protein Kinase ERK in a Model of Kidney Fibrosis
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AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2010)
Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event
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BIOCHEMICAL JOURNAL (2010)
Adam10 Is Essential for Early Embryonic Cardiovascular Development
Chi Zhang et al.
DEVELOPMENTAL DYNAMICS (2010)
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo
David R. Gibb et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Enrichment and analysis of secretory lysosomes from lymphocyte populations
Hendrik Schmidt et al.
BMC IMMUNOLOGY (2009)
Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein
Daosong Xu et al.
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ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase
Thomas Tousseyn et al.
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Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage
Geert van Tetering et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling
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Mitochondrial Reactive Oxygen Species Mediate GPCR-induced TACE/ADAM17-dependent Transforming Growth Factor-α Shedding
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MOLECULAR BIOLOGY OF THE CELL (2009)
Regulated intramembrane proteolysis - A story about sheddases and I-CliPs
Willem G. Annaert et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2009)
The A Disintegrin And Metalloprotease (ADAM) family of sheddases: Physiological and cellular functions
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SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2009)
ERK1/2 Mediate Wounding- and G-protein-Coupled Receptor Ligands-Induced EGFR Activation via Regulating ADAM17 and HB-EGF Shedding
Jia Yin et al.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2009)
PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Posttranslational regulation of Fas ligand function
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Cell Communication and Signaling (2008)
ADAM10 is essential for proteolytic activation of Notch during thymocyte development
Lei Tian et al.
INTERNATIONAL IMMUNOLOGY (2008)
The ADAM metalloproteinases
Dylan R. Edwards et al.
MOLECULAR ASPECTS OF MEDICINE (2008)
2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells
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PROTEOMICS (2008)
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b
Lucas Martin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
Athena Chalaris et al.
BLOOD (2007)
The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells
V. Kirkin et al.
CELL DEATH AND DIFFERENTIATION (2007)
Secretory lysosomes and their cargo in T and NK cells
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IMMUNOLOGY LETTERS (2007)
Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx
Keisuke Horiuchi et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
The shedding activity of ADAM17 is sequestered in lipid rafts
Edwige Tellier et al.
EXPERIMENTAL CELL RESEARCH (2006)
SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production
Elena Friedmann et al.
NATURE CELL BIOLOGY (2006)
5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-α-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells
Monika Gooz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse
M Lettau et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
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BIOCHEMICAL JOURNAL (2006)
L1 is sequentially processed by two differently activated metalloproteases and presenilin/γ-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth
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MOLECULAR AND CELLULAR BIOLOGY (2005)
ERK-mediated phosphorylation of Thr735 in TNFα-converting enzyme and its potential role in TACE protein trafficking
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JOURNAL OF CELL SCIENCE (2005)
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules
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COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2005)
CTL secretory lysosomes: biogenesis and secretion of a harmful organelle
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ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx
MP Sanderson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
U Sahin et al.
JOURNAL OF CELL BIOLOGY (2004)
Regulation of ADAM12 cell-surface expression by protein kinase C ε
C Sundberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cell-matrix interaction via CD44 is independently regulated by different metal loproteinases activated in response to extracellular Ca2+ influx and PKC activation
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JOURNAL OF CELL BIOLOGY (2004)
The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase
E Six et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Secretory lysosomes
EJ Blott et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Roles of meltrin β/ADAM19 in the processing of neuregulin
K Shirakabe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Trafficking of human ADAM 12-L:: Retention in the trans-Golgi network
S Hougaard et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
Stimulation-induced down-regulation of tumor necrosis factor-α converting enzyme
JR Doedens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Protein kinase C-dependent α-secretase competes with β-secretase for cleavage of amyloid-β precursor protein in the trans-Golgi network
DM Skovronsky et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
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