相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Stapled Peptides with Improved Potency and Specificity That Activate p53
Christopher J. Brown et al.
ACS CHEMICAL BIOLOGY (2013)
Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors
Masaki Miyazaki et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins
Karim M. ElSawy et al.
CELL CYCLE (2013)
In Vitro Selection of Mutant HDM2 Resistant to Nutlin Inhibition
Siau Jia Wei et al.
PLOS ONE (2013)
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry
Lenka Hernychova et al.
PROTEOMICS (2013)
Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding
Shubhra Ghosh Dastidar et al.
CELL CYCLE (2012)
Structure-Based Design of Novel Inhibitors of the MDM2-p53 Interaction
Yosup Rew et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structure of the Stapled p53 Peptide Bound to Mdm2
Sohee Baek et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors
Klaus Michelsen et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
Isabelle Ray-Coquard et al.
LANCET ONCOLOGY (2012)
Simulating Molecular Mechanisms of the MDM2-Mediated Regulatory Interactions: A Conformational Selection Model of the MDM2 Lid Dynamics
Gennady M. Verkhivker
PLOS ONE (2012)
What Can We Learn from the Evolution of Protein-Ligand Interactions to Aid the Design of New Therapeutics?
Alicia P. Higueruelo et al.
PLOS ONE (2012)
Targeting the p53 Pathway in Retinoblastoma with Subconjunctival Nutlin-3a
Rachel C. Brennan et al.
CANCER RESEARCH (2011)
Recent Advances in the Therapeutic Perspectives of Nutlin-3
Paola Secchiero et al.
CURRENT PHARMACEUTICAL DESIGN (2011)
Design and Structure of Stapled Peptides Binding to Estrogen Receptors
Chris Phillips et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis
Young-Woo Kim et al.
NATURE PROTOCOLS (2011)
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Grzegorz M. Popowicz et al.
CELL CYCLE (2010)
p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma
G. Liu et al.
DISEASES OF THE ESOPHAGUS (2010)
Diverse somatic mutation patterns and pathway alterations in human cancers
Zhengyan Kan et al.
NATURE (2010)
Pharmacological reactivation of mutant p53: from protein structure to the cancer patient
K. G. Wiman
ONCOGENE (2010)
Quantitative Prediction of Fold Resistance for Inhibitors of EGFR
Trent E. Balius et al.
BIOCHEMISTRY (2009)
A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity
Bartosz Wawrzynow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Discovery and Optimization of Chromenotriazolopyrimidines as Potent Inhibitors of the Mouse Double Minute 2-Tumor Protein 53 Protein-Protein Interaction
John G. Allen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy
Sanjeev Shangary et al.
Annual Review of Pharmacology and Toxicology (2008)
Multiple peptide conformations give rise to similar binding affinities: Molecular simulations of p53-MDM2
Shubhra Ghosh Dastidar et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)
A Fluorescent Two-hybrid Assay for Direct Visualization of Protein Interactions in Living Cells
Kourosh Zolghadr et al.
MOLECULAR & CELLULAR PROTEOMICS (2008)
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug
Frank M. Boeckler et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members
Gregory L. Verdine et al.
CLINICAL CANCER RESEARCH (2007)
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide
Federico Bernal et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Automatic atom type and bond type perception in molecular mechanical calculations
Junmei Wang et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2006)
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding
S Uhrinova et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan
J Boyer et al.
CLINICAL CANCER RESEARCH (2004)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky et al.
SCIENCE (2004)
Development and testing of a general amber force field
JM Wang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
The UMD-p53 database:: New mutations and analysis tools
C Béroud et al.
HUMAN MUTATION (2003)
Computational studies of the resistance patterns of mutant HIV-1 aspartic proteases towards ABT-538 (ritonavir) and design of new derivatives
AC Nair et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2002)
Molecular mechanism of the interaction between MDM2 and p53
O Schon et al.
JOURNAL OF MOLECULAR BIOLOGY (2002)
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
VJN Bykov et al.
NATURE MEDICINE (2002)
Computational study of protein specificity: The molecular basis of HIV-1 protease drug resistance
W Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Thermodynamics of p53 binding to hdm2(1-126): Effects of phosphorylation and p53 peptide length
ZH Lai et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2000)
分享论文
