期刊
PLOS ONE
卷 8, 期 9, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0074855
关键词
-
资金
- Agence pour la Recherche Contre le SIDA (ANRS)
- Ensemble contre le SIDA (SIDACTION)
- INSERM
- University Paris-Sud
- Duke CFAR [1P30 AI 64518]
- National Institutes of Health [AI 0678501, AI61734]
- National Institues of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) [AI007392]
The role of Antibody-dependent cellular cytotoxicity (ADCC) responses in HIV-1 controllers is still unclear due to the heterogeneity of these patients. We analyzed 67 HIV-1 controllers and found significantly higher levels of ADCC antibodies in controllers versus viremic subjects (p = 0.017). Moreover, multivariate analysis revealed significantly higher ADCC titers in HLA B57-controllers compared to HLA-B57+ ones (p = 0.0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据