期刊
PLOS ONE
卷 8, 期 8, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0073884
关键词
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资金
- National Natural Science Foundation of China [30960011, 31071724]
- Natural Science Foundation of Jiangxi Province, China [2009GZN0030, 2010GZN0037]
- Key Technology R&D Program of Jiangxi Province, China [2007BN14002]
Antifungalmycin 702, a new polyene macrolide antibiotic produced by Streptomyces padanus JAU4234, has a broad antifungal activity and may have potential future agricultural and/or clinical applications. However, the mechanism of antifungal action of antifungalmycin 702 remains unknown. Antifungalmycin 702 strongly inhibited mycelial growth and sclerotia formation/germination of Rhizoctonia solani. When treated with antifungalmycin 702, the hyphae morphology of R. solani became more irregular. The membrane and the cellular organelles were disrupted and there were many vacuoles in the cellular space. The lesion in the plasma membrane was detected through the increase of membrane permeability, lipid peroxidation and leakage of cell constituents. In summary, antifungalmycin 702 may exert its antifungal activity against R. solani by changing the structure of cell membranes and the cytoskeleton and interacting with the organelles.
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