期刊
ASAIO JOURNAL
卷 61, 期 1, 页码 61-70出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MAT.0000000000000158
关键词
acellular ventricular extracellular matrix; cardiac tissue engineering; twitch force; 3D bio-artificial heart muscle
资金
- NIBIB NIH HHS [R01 EB011516] Funding Source: Medline
Current therapies in left ventricular systolic dysfunction and end-stage heart failure include mechanical assist devices or transplant. The development of a tissue-engineered integrative platform would present a therapeutic option that overcomes the limitations associated with current treatment modalities. This study provides a foundation for the fabrication and preliminary viability of the acellular ventricular extracellular matrix (AVEM) model. Acellular ventricular extracellular matrix was fabricated by culturing 4 million rat neonatal cardiac cells around an excised acellular ventricular segment. Acellular ventricular extracellular matrix generated a maximum spontaneous contractile force of 388.3 mu N and demonstrated a Frank-Starling relationship at varying pretensions. Histologic assessment displayed cell cohesion and adhesion within the AVEM as a result of passive cell seeding.
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