相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin
Sohee Baek et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells
Marie-Anne Hospital et al.
BLOOD (2012)
A potential therapeutic target for FLT3-ITD AML: PIM1 kinase
Amir T. Fathi et al.
LEUKEMIA RESEARCH (2012)
Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease
Gerald W. Hart et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia
Lisa S. Chen et al.
BLOOD (2011)
Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
Mark Levis et al.
BLOOD (2011)
FLT3 inhibitors: a story of the old and the new
Amir Fathi et al.
CURRENT OPINION IN HEMATOLOGY (2011)
c-Cbl and Cbl-b Ligases Mediate 17-Allylaminodemethoxygeldanamycin-induced Degradation of Autophosphorylated Flt3 Kinase with Internal Tandem Duplication through the Ubiquitin Proteasome Pathway
Gaku Oshikawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Phase I/II Study of Combination Therapy With Sorafenib, Idarubicin, and Cytarabine in Younger Patients With Acute Myeloid Leukemia
Farhad Ravandi et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3
Thomas Fischer et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
Pim-1 Kinase Protects P-Glycoprotein from Degradation and Enables Its Glycosylation and Cell Surface Expression
Yingqiu Xie et al.
MOLECULAR PHARMACOLOGY (2010)
AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
Patrick P. Zarrinkar et al.
BLOOD (2009)
Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality
Dirk Schmidt-Arras et al.
BLOOD (2009)
Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia
Soheil Meshinchi et al.
CLINICAL CANCER RESEARCH (2009)
Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration
Rebekka Grundler et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2009)
Mislocalized Activation of Oncogenic RTKs Switches Downstream Signaling Outcomes
Chunaram Choudhary et al.
MOLECULAR CELL (2009)
Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation
Xuerong Wang et al.
CANCER RESEARCH (2008)
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels
Daisuke Morishita et al.
CANCER RESEARCH (2008)
Pim-1 Kinase Phosphorylates and Stabilizes RUNX3 and Alters Its Subcellular Localization
Hye-Ryun Kim et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2008)
Pim kinase-dependent inhibition of c-Myc degradation
Y. Zhang et al.
ONCOGENE (2008)
Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload
John A. Muraski et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The 44-kDa pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells
Yingqiu Xie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Pim-1 kinase-dependent phosphorylation of p21Cipl/WAF1 regulates its stability and cellular localization in H1299 cells
Yandong Zhang et al.
MOLECULAR CANCER RESEARCH (2007)
Calreticulin and Hsp90 stabilize the human insulin receptor and promote its mobility in the endoplasmic reticulum
Rowena R. Ramos et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cells
Kyu-Tae Kim et al.
BRITISH JOURNAL OF HAEMATOLOGY (2007)
Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase
Sheldon Holder et al.
MOLECULAR CANCER THERAPEUTICS (2007)
Constitutively activated FLT3 phosphorylates BAD partially through Pim-1
Kyu-Tae Kim et al.
BRITISH JOURNAL OF HAEMATOLOGY (2006)
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
Jennifer L. Rocnik et al.
BLOOD (2006)
The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C
M Bachmann et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2006)
Structure and substrate specificity of the Pim-1 kinase
AN Bullock et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases
DE Schmidt-Arras et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Structural basis of constitutive activity and a unique nucleotide binding mode of human PIM-1 kinase
KC Qian et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Pim-1 is up-regulated by constitutively activated FLT3 and plays a role in FLT3-mediated cell survival
KT Kim et al.
BLOOD (2005)
Pim-1 kinase promotes inactivation of the pro-apoptotic bad protein by phosphorylating it on the Ser112 gatekeeper site
TLT Aho et al.
FEBS LETTERS (2004)
Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors
H Mikkers et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Cotreatment with 17-allylamino-demethoxygeldanamycin and FLT-3 kinase inhibitor PKC412 is highly effective against human acute myelogenous leukemia cells with mutant FLT-3
P George et al.
CANCER RESEARCH (2004)
FLT3 mutations in acute myeloid leukemia cell lines
H Quentmeier et al.
LEUKEMIA (2003)
Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors
Y Minami et al.
LEUKEMIA (2002)
Pim serine/threonine kinases regulate the stability of Socs-1 protein
XP Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
LM Kelly et al.
BLOOD (2002)