期刊
PLOS ONE
卷 8, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0071042
关键词
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资金
- Academy of Finland [118590, 137826, 131593]
- Nordforsk for the Sysdiet consortium
- Juselius Foundation
- Juho Vainio Foundation
- Finnish Foundation for Cardiovascular Research
- Finnish Diabetes Research Foundation
- Academy of Finland (AKA) [137826, 118590, 137826, 118590] Funding Source: Academy of Finland (AKA)
Vitamin D deficiency has been associated with an increased risk of developing a number of diseases. Here we investigated samples from 71 pre-diabetic individuals of the VitDmet study, a 5-month high dose vitamin D-3 intervention trial during Finnish winter, for their changes in serum 25-hydroxyvitamin D-3 (25(OH)D-3) concentrations and the expression of primary vitamin D target genes in peripheral blood mononuclear cells and adipose tissue. A negative correlation between serum concentrations of parathyroid hormone and 25(OH)D-3 suggested an overall normal physiological vitamin D response among the participants. The genes CD14 and thrombomodulin (THBD) are up-regulated primary vitamin D targets and showed to be suitable gene expression markers for vitamin D signaling in both primary tissues. However, in a ranking of the samples concerning their expected response to vitamin D only the top half showed a positive correlation between the changes of CD14 or THBD mRNA and serum 25(OH)D-3 concentrations. Interestingly, this categorization allows unmasking a negative correlation between changes in serum concentrations of 25(OH)D-3 and the inflammation marker interleukin 6. We propose the genes CD14 and THBD as transcriptomic biomarkers, from which the effects of a vitamin D-3 supplementation can be evaluated. These biomarkers allow the classification of subjects into those, who might benefit from a vitamin D-3 supplementation, and others who do not.
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