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Leslie Crews et al.
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L. Lannfelt et al.
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Tania F. Gendron et al.
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S. Salloway et al.
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Claudie Hooper et al.
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Nicolas Le Novere et al.
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P Watcharasit et al.
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M Hucka et al.
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DL Craft et al.
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P Watcharasit et al.
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M Rapoport et al.
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MM Pallitto et al.
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F Bard et al.
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