期刊
PLOS ONE
卷 8, 期 9, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0074696
关键词
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资金
- Royal Society
- Bill and Melinda Gates Foundation [49446, 1032350]
- NIH [R01 GM083983-01]
- RAPIDD program of the Science & Technology Directorate, Department of Homeland Security
- Fogarty International Center, National Institutes of Health
- Wellcome Trust
- Medical Research Council
- NIH/NIAID [U19AI089674]
- MRC [G0901135] Funding Source: UKRI
- Medical Research Council [G0901135] Funding Source: researchfish
Metapopulation rescue effects are thought to be key to the persistence of many acute immunizing infections. Yet the enhancement of persistence through spatial coupling has not been previously quantified. Here we estimate the metapopulation rescue effects for four childhood infections using global WHO reported incidence data by comparing persistence on island countries vs all other countries, while controlling for key variables such as vaccine cover, birth rates and economic development. The relative risk of extinction on islands is significantly higher, and approximately double the risk of extinction in mainland countries. Furthermore, as may be expected, infections with longer infectious periods tend to have the strongest metapopulation rescue effects. Our results quantitate the notion that demography and local community size controls disease persistence.
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