期刊
PLOS ONE
卷 8, 期 6, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0067323
关键词
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资金
- European Union New OSH ERA research programme
- Finnish Work Environment Fund, Finland
- Swedish Council for Working Life and Social Research, Sweden
- German Social Accident Insurance, Germany
- Danish National Research Centre for the Working Environment, Denmark
- Academy of Finland [132944]
- BUPA Foundation [22094477]
- British Heart Foundation (BHF), UK
- Heinz Nixdorf Foundation, Germany
- German Ministry of Education and Science
- German Research Foundation
- Medical Research Council, UK [K013351]
- US National Institutes of Health [R01HL036310, R01AG034454]
- Economic and Social Research Council, UK
- British Heart Foundation [RG/07/008/23674, RG/13/2/30098] Funding Source: researchfish
- Economic and Social Research Council [ES/F02679X/1, ES/J023299/1] Funding Source: researchfish
- Medical Research Council [MR/K013351/1, G0701830, G0601647, G8802774, MR/K026992/1, G0100222, G19/35, G1000616, G0902037] Funding Source: researchfish
- ESRC [ES/J023299/1, ES/F02679X/1] Funding Source: UKRI
- MRC [G1000616, G0601647, MR/K013351/1, G0902037, G0701830] Funding Source: UKRI
Background: Job strain is associated with an increased coronary heart disease risk, but few large-scale studies have examined the relationship of this psychosocial characteristic with the biological risk factors that potentially mediate the job strain - heart disease association. Methodology and Principal Findings: We pooled cross-sectional, individual-level data from eight studies comprising 47,045 participants to investigate the association between job strain and the following cardiovascular disease risk factors: diabetes, blood pressure, pulse pressure, lipid fractions, smoking, alcohol consumption, physical inactivity, obesity, and overall cardiovascular disease risk as indexed by the Framingham Risk Score. In age-, sex-, and socioeconomic status-adjusted analyses, compared to those without job strain, people with job strain were more likely to have diabetes (odds ratio 1.29; 95% CI: 1.11-1.51), to smoke (1.14; 1.08-1.20), to be physically inactive (1.34; 1.26-1.41), and to be obese (1.12; 1.04-1.20). The association between job strain and elevated Framingham risk score (1.13; 1.03-1.25) was attributable to the higher prevalence of diabetes, smoking and physical inactivity among those reporting job strain. Conclusions: In this meta-analysis of work-related stress and cardiovascular disease risk factors, job strain was linked to adverse lifestyle and diabetes. No association was observed between job strain, clinic blood pressure or blood lipids.
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