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Suppression of Her2/neu expression through ILK inhibition is regulated by a pathway involving TWIST and YB-1
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Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition
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Combined inhibition of integrin linked kinase and FMS-like tyrosine kinase 3 is cytotoxic to acute myeloid leukemia progenitor cells
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Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system
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QLT0267, a small molecule inhibitor targeting integrin-linked kinase ( ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model
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Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
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CANCER RESEARCH (2008)
Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage
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Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK)
Lincoln A. Edwards et al.
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Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
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JOURNAL OF CELL BIOLOGY (2007)
Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells
Yoko Tabe et al.
CANCER RESEARCH (2007)
Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy
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Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck
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Integrin-linked kinase activity is associated with interleukin-1a-induced progressive behavior of pancreatic cancer and poor patient survival
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ONCOGENE (2006)
ILK over-expression in human colon cancer progression correlates with activation of beta-catenin, down-regulation of E-cadherin and activation of the Akt-FKHR pathway
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Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma
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Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer
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Integrin-linked kinase mediates bone morphogenetic protein 7-dependent renal epithelial cell morphogenesis
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