期刊
PLOS ONE
卷 8, 期 5, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0062788
关键词
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资金
- National 973 Basic Research Program of China [2011CB503906, 2012CB518603]
- National High-tech Research and Development Program of China [2012AA02A510]
- Program of Introducing Talents of Discipline to Universities [B07035]
- State Program of National Natural Science Foundation of China for Innovative Research Group [81021001]
- National Natural Science Foundation of China [81100102, 81100147, 81100207, 81170136, 81170275, 81270350]
- Graduate Independent Innovation Foundation of Shandong University
Background: We recently found that overexpression of angiotensin (Ang)-converting enzyme 2, which metabolizes Ang-II to Ang-(1-7) and Ang-I to Ang-(1-9), may prevent diabetes-induced left ventricular remodeling and dysfunction in rats. Our objective was to evaluate the association of plasma Ang-(1-7) level and left ventricular function in patients with type 2 diabetes mellitus. Methodology/Principal Findings: We measured the left ventricular ejection fraction (EF), ratio of early to late left ventricular filling velocity (E/A) and ratio of early diastolic mitral inflow to annular velocity (E/Ea) by ultrasonography in 110 patients with type 2 diabetes mellitus for more than 5 years. Anthropometric and fasting blood values were obtained from medical records. The plasma Ang-(1-7) level in patients with a poor EF (<50%) was significantly lower than that in patients with EF >= 50%; the level in patients with E/A <1 was significantly lower than that in patients with E/A >= 1; and the level in patients with E/Ea >15 was significantly lower than that in patients with E/Ea <= 15. Ang-(1-7) level was negatively correlated with E/Ea and Log-N-terminal pro-B-type natriuretic peptide and positively with EF and E/A. Stepwise multiple regression analysis revealed that Ang-(1-7), hemoglobin A1c and Ang-II levels as well as duration of diabetes predicted EF; Ang-(1-7) level, fasting blood glucose, low-density lipoprotein cholesterol level and duration of diabetes predicted E/A; and Ang-(1-7) and hemoglobin A1c levels predicted E/Ea. Conclusions/Significance: Plasma Ang-(1-7) level is independently associated with left ventricular function in patients with type 2 diabetes mellitus and may be a biomarker for assessing cardiac function in such patients.
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