期刊
PLOS ONE
卷 8, 期 5, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0063337
关键词
-
资金
- National Natural Science Foundation of China [30770790, 30800377, 31171105]
- National Institutes of Health
Cardiac K-ATP channels link metabolism with electrical activity. They are implicated in arrhythmias, secretion of atrial natriuretic peptide and protection of the heart from hypertrophy and failure. These processes may involve mechanosensitivity. K-ATP channels can be activated by mechanical stimulation and disrupting the cortical actin increases the activity. We propose that K-ATP channels are modulated by local bilayer tension and this tension is affected by cortical F-actin. Here we measured K-ATP background activity and stretch sensitivity with inside-out patches of rat ventricular myocytes before and after disrupting F-actin. Disrupting F-actin potentiated background activity but did not influence the slope sensitivity in the semilog relationship of NPo vs. suction that is a measure of the change in dimensions between closed and open states. Thus actin alters prestress on the channel probably by parallel elastic sharing of mean cortical tension with the bilayer.
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