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The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition
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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
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TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase
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Shroom regulates epithelial cell shape via the apical positioning of an actomyosin network
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Aberrant β-catenin signaling in tuberous sclerosis
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Distinct effects of single amino-acid changes to tuberin on the function of the tuberin-hamartin complex
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Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
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TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
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Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
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Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration
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The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton
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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
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Actin cable dynamics and Rho/Rock orchestrate a polarized cytoskeletal architecture in the early steps of assembling a stratified epithelium
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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
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A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
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CELL (2001)
Tuberin-dependent membrane localization of polycystin-1:: A functional link between polycystic kidney disease and the TSC2 tumor suppressor gene
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Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
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The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination
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A new Western blotting method using polymer immunocomplexes: Detection of Tsc1 and Tsc2 expression in various cultured cell lines
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The TSC1 gene product, hamartin, negatively regulates cell proliferation
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HUMAN MOLECULAR GENETICS (2000)
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
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