期刊
PLOS ONE
卷 8, 期 3, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0060643
关键词
-
资金
- German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) graduate school [GRK 1043]
- DFG [WA 1600/3-1, SFB/TR 52, FOR1336]
B cells were first discovered as antibody producing cell as B-1 B cells and finally as effector cells. In recent years their capacity to serve as antigen presenting cells is Increasingly appreciated, and better tools are needed to study their function. We have previously described a new mouse model, the IDTR mice, that allow for the Cre-mediated expression of the diphtheria toxin receptor, thus rendering cells that express the Cre-recombinase sensitivity to diphtheria toxin. Herein describe a new mouse line, the B-DTR mice, where the CD19-Cre was crossed to the iDTR mice. B-DTR allows for the efficient and cost-effective depletion of different B cell subpopulations, but only partially plasma cells. These mice can therefore be used to study the importance of B cells versus plasma cells in different immune responses and autoimmune diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据