4.6 Article

SEED Servers: High-Performance Access to the SEED Genomes, Annotations, and Metabolic Models

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PLOS ONE
卷 7, 期 10, 页码 -

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PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0048053

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资金

  1. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services [HHSN266200400042C, HHSN272200900040C]
  2. U.S. Department of Energy [DE-AC02-06CH11357, DE-SC0004921]
  3. U.S. Department of Energy University Knowledgebase program
  4. National Science Foundation Division of Biological Infrastructure [NSF DBI-0850356]
  5. National Science Foundation Division of Environmental Biology [NSF DEB-1046413]
  6. Argonne, a U.S. Department of Energy Office of Science laboratory [DE-AC02-06CH11357, DE-SC0004921]
  7. Direct For Biological Sciences
  8. Div Of Biological Infrastructure [0850356] Funding Source: National Science Foundation
  9. Division Of Environmental Biology
  10. Direct For Biological Sciences [1046413] Funding Source: National Science Foundation

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The remarkable advance in sequencing technology and the rising interest in medical and environmental microbiology, biotechnology, and synthetic biology resulted in a deluge of published microbial genomes. Yet, genome annotation, comparison, and modeling remain a major bottleneck to the translation of sequence information into biological knowledge, hence computational analysis tools are continuously being developed for rapid genome annotation and interpretation. Among the earliest, most comprehensive resources for prokaryotic genome analysis, the SEED project, initiated in 2003 as an integration of genomic data and analysis tools, now contains >5,000 complete genomes, a constantly updated set of curated annotations embodied in a large and growing collection of encoded subsystems, a derived set of protein families, and hundreds of genome-scale metabolic models. Until recently, however, maintaining current copies of the SEED code and data at remote locations has been a pressing issue. To allow high-performance remote access to the SEED database, we developed the SEED Servers (http://www.theseed.org/servers): four network-based servers intended to expose the data in the underlying relational database, support basic annotation services, offer programmatic access to the capabilities of the RAST annotation server, and provide access to a growing collection of metabolic models that support flux balance analysis. The SEED servers offer open access to regularly updated data, the ability to annotate prokaryotic genomes, the ability to create metabolic reconstructions and detailed models of metabolism, and access to hundreds of existing metabolic models. This work offers and supports a framework upon which other groups can build independent research efforts. Large integrations of genomic data represent one of the major intellectual resources driving research in biology, and programmatic access to the SEED data will provide significant utility to a broad collection of potential users.

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