期刊
PLOS ONE
卷 7, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0047990
关键词
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资金
- National Natural Science Foundation of China [30945204]
- Provincial department of Finance, Guangxi Zhuang Autonomous Region, China [2009GJCJ150, 201012MS060, 2012GXNSFFA060009]
- Provincial department of Education, Guangxi Zhuang Autonomous Region, China [2009GJCJ150, 201012MS060, 2012GXNSFFA060009]
IgM provides a first line of defense during microbial infections. Serum IgM levels are detected routinely in clinical practice. And IgM is a genetically complex trait. We conducted a two-stage genome-wide association study (GWAS) to identify genetic variants affecting serum IgM levels in a Chinese population of 3495, including 1999 unrelated subjects in the first stage and 1496 independent individuals in the second stage. Our data show that a common single nucleotide polymorphism (SNP), rs11552708 located in the TNFSF13 gene was significantly associated with IgM levels (p=5.00x10(-7) in first stage, p=1.34x10(-3) in second stage, and p=4.22x10(-9) when combined). Besides, smoking was identified to be associated with IgM levels in both stages (P<0.05), but there was no significant interaction between smoking and the identified SNP (P>0.05). It is suggested that TNFSF13 may be a susceptibility gene affecting serum IgM levels in Chinese male population.
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