期刊
PLOS ONE
卷 7, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0050933
关键词
-
资金
- Liaison Committee between the Central Norway Regional Health Authority
- Norwegian University of Science and Technology
- Swedish Research Council
- Swedish Council of Working Life and Social Research
- Norwegian Council on Cardiovascular Disease
- Foundation for Cardiovascular Research at St. Olav's Hospital
- Norwegian State Railways
- Roche Norway Incorporated
- Norwegian Research Council Grant for Outstanding Young Investigators
- K.G. Jebsen Foundation
- Norwegian Council of Cardiovascular Disease
Background: Insomnia is associated with increased risk of coronary heart disease (CHD), but the underlying mechanisms are not understood. To our knowledge, no previous studies have examined insomnia in relation to endothelial function, an indicator of preclinical atherosclerosis. Our aim was to assess the association of insomnia with endothelial function in a large population based study of healthy individuals. Methods: A total of 4 739 participants free from known cardiovascular or pulmonary diseases, cancer, and sarcoidosis, and who were not using antihypertensive medication were included in the study. They reported how often they had experienced difficulties falling asleep at night, repeated awakenings during the night, early awakenings without being able to go back to sleep, and daytime sleepiness. Endothelial function was measured by flow mediated dilation (FMD) derived from the brachial artery. Results: We found no consistent association between the insomnia symptoms and endothelial function in multiadjusted models, but individual insomnia symptoms may be related to endothelial function. Among women who reported early awakenings, endothelial function may be lower than in women without this symptom (p = 0.03). Conclusions: This study provided no evidence that endothelial function, an early indicator of atherosclerosis, is an important linking factor between insomnia and CHD. Further studies are needed to explore the complex interrelation between sleep and cardiovascular pathology. Citation: Strand LB, Laugsand LE, Skaug E-A, Ellingsen O, Madssen E, et al. (2012) Insomnia and Endothelial Function - The HUNT 3 Fitness Study. PLoS ONE 7(12): e50933. doi:10.1371/journal.pone.0050933
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据