期刊
PLOS ONE
卷 7, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0034152
关键词
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资金
- National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology (MEST)
- Translational Research Center for Protein Function Control [2009-0083522]
- Mid-career Researcher Program [2010-0026844]
- Stem Cell Research Project [2010-0020235]
- Ministry of Knowledge Economy (through the Korea Research Institute of Chemical Technology) [SI-095]
Background: Alopecia is the common hair loss problem that can affect many people. However, current therapies for treatment of alopecia are limited by low efficacy and potentially undesirable side effects. We have identified a new function for valproic acid (VPA), a GSK3 beta inhibitor that activates the Wnt/beta-catenin pathway, to promote hair re-growth in vitro and in vivo. Methodology/Principal Findings: Topical application of VPA to male C3H mice critically stimulated hair re-growth and induced terminally differentiated epidermal markers such as filaggrin and loricrin, and the dermal papilla marker alkaline phosphatase (ALP). VPA induced ALP in human dermal papilla cells by up-regulating the Wnt/beta-catenin pathway, whereas minoxidil (MNX), a drug commonly used to treat alopecia, did not significantly affect the Wnt/beta-catenin pathway. VPA analogs and other GSK3 beta inhibitors that activate the Wnt/beta-catenin pathway such as 4-phenyl butyric acid, LiCl, and BeCl2 also exhibited hair growth-promoting activities in vivo. Importantly, VPA, but not MNX, successfully stimulate hair growth in the wounds of C3H mice. Conclusions/Significance: Our findings indicate that small molecules that activate the Wnt/beta-catenin pathway, such as VPA, can potentially be developed as drugs to stimulate hair re-growth.
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