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Deletion of the CUL4B Gene in a Boy With Mental Retardation, Minor Facial Anomalies, Short Stature, Hypogonadism, and Ataxia
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AMERICAN JOURNAL OF MEDICAL GENETICS PART A (2010)
A novel nonsense mutation in CUL4B gene in three brothers with X-linked mental retardation syndrome
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Phenotypic annotation of the mouse X chromosome
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Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaks
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Cullins in Human Intra-Uterine Growth Restriction: Expressional and Epigenetic Alterations
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Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression
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CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis
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Proliferation defects and genome instability in cells lacking Cul4A
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Cul4A is required for hematopoietic cell viability and its deficiency leads to apoptosis
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Cullin-RING ubiquitin ligases: global regulation and activation cycles
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Cell Division (2008)
Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model
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AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase
Fumiaki Ohtake et al.
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Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation
Yongxin Zou et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremor
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AMERICAN JOURNAL OF HUMAN GENETICS (2007)
Stealing the spotlight: CUL4-DDB1 ubiquitin ligase docks WD40-repeat proteins to destroy
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CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation
Leigh Ann Higa et al.
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DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases
Yizhou Joseph He et al.
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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
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Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues
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Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27(Kip1) and cyclin E degradation
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The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis
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Function and regulation of Cullin-RING ubiquitin ligases
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis
T Arai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis
S Doronkin et al.
DEVELOPMENTAL CELL (2003)
CUL-4A is critical for early embryonic development
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