期刊
PLOS ONE
卷 7, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0031928
关键词
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资金
- Fundacion para la Investigacion y Prevencion del SIDA en Espana (FIPSE) [36558/06, 36641/07, 36779/08, 360766/09, 360737/09]
- United States National Institute of Health NIH-NIAID [N01-AI-30024]
- Red Tematica Cooperativa de Investigacion en SIDA (Red de grupos) of the Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss) [173]
- [SAF 2007-61036]
- [SAF 2010-17226]
- ICREA Funding Source: Custom
Objective: To study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient. Methodology and Principal Findings: We studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naive patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs. Conclusions: The study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC.
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