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The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling
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Hedgehog Signaling in Development and Cancer
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The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
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Multiple roles for lipids in the Hedgehog signalling pathway
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Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog
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Patched1 regulates Hedgehog signaling at the primary cilium
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Region-specific requirement for cholesterol modification of sonic hedgehog in patterning the telencephalon and spinal cord
Xi Huang et al.
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Cholesterol modification restricts the spread of Shh gradient in the limb bud
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Signal dynamics in Sonic hedgehog tissue patterning
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A highly conserved amino-terminal region of sonic hedgehog is required for the formation of its freely diffusible multimeric form
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Lipoprotein particles are required for Hedgehog and Wingless signalling
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Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates
MH Chen et al.
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Synergistic and antagonistic roles of the Sonic hedgehog N- and C-terminal lipids
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Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities
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Activity-dependent internalization of smoothened mediated by β-arrestin 2 and GRK2
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Hedgehog signalling in the mouse requires intraflagellar transport proteins
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A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
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Malformations of the craniofacial region: Evolutionary, embryonic, genetic, and clinical perspectives
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Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched
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Patched acts catalytically to suppress the activity of Smoothened
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Hedgehog signaling in animal development: paradigms and principles
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Skinny Hedgehog, an acyltransferase required for palmitoylation and activity of the Hedgehog signal
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Sightless has homology to transmembrane acyltransferases and is required to generate active Hedgehog protein
JD Lee et al.
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A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of Sonic hedgehog in the neural tube
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MOLECULAR CELL (2001)
A freely diffusible form of Sonic hedgehog mediates long-range signalling
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Cholesterol modification of sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
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CELL (2001)
Enhanced potency of human sonic hedgehog by hydrophobic modification
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TM Jessell
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
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Genetics of ventral forebrain development and holoprosencephaly
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Mapping Sonic hedgehog-receptor interactions by steric interference
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)