相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Impaired SHP2-Mediated Extracellular Signal-Regulated Kinase Activation Contributes to Gefitinib Sensitivity of Lung Cancer Cells with Epidermal Growth Factor Receptor-Activating Mutations
Matthew J. Lazzara et al.
CANCER RESEARCH (2010)
Active Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migration
Catherine Qiurong Pan et al.
JOURNAL OF CELL SCIENCE (2010)
The ERK signaling cascade-Views from different subcellular compartments
Zhong Yao et al.
BIOFACTORS (2009)
Simulation of crosstalk between small GTPase RhoA and EGFR-ERK signaling pathway via MEKK1
Hu Li et al.
BIOINFORMATICS (2009)
Characterization of kinase suppressor of Ras-1 expression and anticancer drug sensitivity in human cancer cell lines
Scott M. Stoeger et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2009)
Differential requirement for MEK Partner 1 in DU145 prostate cancer cell migration
Electa R. Park et al.
CELL COMMUNICATION AND SIGNALING (2009)
The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes
Shigeyki Nada et al.
EMBO JOURNAL (2009)
The Mitogen-Activated Protein Kinase Scaffold KSR1 Is Required for Recruitment of Extracellular Signal-Regulated Kinase to the Immunological Synapse
Emanuele Giurisato et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
KSR1 Modulates the Sensitivity of Mitogen-Activated Protein Kinase Pathway Activation in T Cells without Altering Fundamental System Outputs
Joseph Lin et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Scaffold proteins and immune-cell signalling
Andrey S. Shaw et al.
NATURE REVIEWS IMMUNOLOGY (2009)
Simulation of the regulation of EGFR endocytosis and EGFR-ERK signaling by endophilin-mediated RhoA-EGFR crosstalk
Choong Yong Ung et al.
FEBS LETTERS (2008)
Epidermal growth factor receptor regulates osteoclast differentiation and survival through cross-talking with RANK signaling
Tacghee Yi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling
K. Shtiegman et al.
ONCOGENE (2007)
Scaffold proteins confer diverse regulatory properties to protein kinase cascades
Jason W. Locasale et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A perspective
Ashok K. Pullikuth et al.
CELLULAR SIGNALLING (2007)
A domain-based approach to predict protein-protein interactions
Mudita Singhal et al.
BMC BIOINFORMATICS (2007)
Development of Rho-kinase inhibitors for cardiovascular medicine
Hiroaki Shimokawa et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2007)
Shp2 in PC12 cells: NGF versus EGF signalling
Amelia D'Alessio et al.
CELLULAR SIGNALLING (2007)
MAP kinase signalling pathways in cancer
A. S. Dhillon et al.
ONCOGENE (2007)
The role of Shp2 (PTPN11) in cancer
M. Golam Mohi et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2007)
Epidermal growth factor receptor degradation: An alternative view of oncogenic pathways
Andreas Kirisits et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis
David Teis et al.
JOURNAL OF CELL BIOLOGY (2006)
Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin
Naoya Takeda et al.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2006)
Scaffolding protein Grb2-associated binder 1 sustains epidermal growth factor-induced mitogenic and survival signaling by multiple positive feedback loops
Anatoly Kiyatkin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
MAPK signal specificity: the right place at the right time
Leon O. Murphy et al.
TRENDS IN BIOCHEMICAL SCIENCES (2006)
Targeting Rho and Rho-kinase in the treatment of cardiovascular disease
K Budzyn et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way
M Lerdrup et al.
JOURNAL OF CELL SCIENCE (2006)
Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis
CS Xue et al.
CANCER RESEARCH (2006)
Rho kinase: a target for treating urinary bladder dysfunction?
Stephan L. M. Peters et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
W Kolch
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase
T Kaneko et al.
GENES TO CELLS (2005)
The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis
RL Kortum et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
M Ebisuya et al.
JOURNAL OF CELL SCIENCE (2005)
Prediction and validation of the distinct dynamics of transient and sustained ERK activation
S Sasagawa et al.
NATURE CELL BIOLOGY (2005)
Sensitivity, principal component and flux analysis applied to signal transduction: the case of epidermal growth factor mediated signaling
G Liu et al.
BIOINFORMATICS (2005)
The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells
RL Kortum et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Model analysis of difference between EGF pathway and FGF pathway
S Yamada et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Not just a sink: endosomes in control of signal transduction
M Miaczynska et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation
F Yan et al.
JOURNAL OF CLINICAL INVESTIGATION (2004)
MAPK cascade possesses decoupled controllability of signal amplification and duration
K Mayawala et al.
BIOPHYSICAL JOURNAL (2004)
Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists
T Vomastek et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling
YM Agazie et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors
T Araki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
BG Neel et al.
TRENDS IN BIOCHEMICAL SCIENCES (2003)
Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling
M Costa et al.
JOURNAL OF ENVIRONMENTAL MONITORING (2003)
Regulation of map kinase signaling modules by scaffold proteins in mammals
DK Morrison et al.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY (2003)
Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
D Teis et al.
DEVELOPMENTAL CELL (2002)
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
A Nguyen et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Computational modeling of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors
B Schoeberl et al.
NATURE BIOTECHNOLOGY (2002)
Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors
P Soubeyran et al.
NATURE (2002)
KSR is a scaffold required for activation of the ERK/MAPK module
F Roy et al.
GENES & DEVELOPMENT (2002)
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment
W Wunderlich et al.
JOURNAL OF CELL BIOLOGY (2001)
Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy
A Sorkin et al.
CURRENT BIOLOGY (2000)
Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells
FA Brightman et al.
FEBS LETTERS (2000)
Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling
J Müller et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Sequential steps in clathrin-mediated synaptic vesicle endocytosis
L Brodin et al.
CURRENT OPINION IN NEUROBIOLOGY (2000)
Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties
A Levchenko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Signal transduction: hanging on a scaffold
WR Burack et al.
CURRENT OPINION IN CELL BIOLOGY (2000)