期刊
PLOS ONE
卷 6, 期 6, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0020703
关键词
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资金
- Ovarian Cancer Association Consortium
- U.S. National Institutes of Health [R01 CA58598, N01-CN-55424, N01-PC-67001]
- USC: Public Health Service [CA14089, CA17054, CA61132, CA63464, N01-PC-67010, R03-CA113148]
- California Department of Health Services [050-E8709]
- UKO: Cancer Research UK
- Eve Appeal
- OAK Foundation
- Department of Health's NIHR Biomedical Research Centre
- STA: the U. S. National Institutes of Health/National Cancer Institute [U01CA71966, R01CA16056, U01CA69417, K07CA143047]
- SEA: Cancer Research United Kingdom
- POL: U.S. National Cancer Institute, National Institutes of Health, Division of Cancer Epidemiology and Genetics (POL) National Cancer Institute [R01-CA-76016 (NCO)]
- NCO: the National Cancer Institute [R01-CA-76016]
- MAL: Mermaid 1
- Danish Cancer Society
- National Cancer Institute [R01-CA-61107]
- Australian Ovarian Cancer Study
- Australian Cancer Study: US Army Medical Research and Material Command [DAMD17-01-1-0729]
- Cancer Council Victoria
- Cancer Council Queensland
- Cancer Council New South Wales
- Cancer Council South Australia
- Cancer Council Tasmania
- Cancer Foundation of Western Australia
- USC [00-01389V-20170, 2110200]
- U.S. Public Health Service [CA14089, CA17054, CA61132, CA63464, N01-PC-67010, R03-CA113148]
- National Health and Medical Research Council of Australia [199600, 400281]
- Cancer Research UK
- The Francis Crick Institute [10124] Funding Source: researchfish
The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged <= 50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.
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