期刊
PLOS ONE
卷 6, 期 2, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0014698
关键词
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资金
- National and Health Medical Research Council (NHMRC)
- St. Vincent's Clinic Foundation, Sydney
- University of New South Wales, Sydney, Australia
- Grants-in-Aid for Scientific Research [21590353] Funding Source: KAKEN
The kynurenine pathway (KP) of tryptophan metabolism is linked to antimicrobial activity and modulation of immune responses but its role in stem cell biology is unknown. We show that human and mouse mesenchymal and neural stem cells (MSCs and NSCs) express the complete KP, including indoleamine 2,3 dioxygenase 1 (IDO) and IDO2, that it is highly regulated by type I (IFN-beta) and II interferons (IFN-gamma), and that its transcriptional modulation depends on the type of interferon, cell type and species. IFN-gamma inhibited proliferation and altered human and mouse MSC neural, adipocytic and osteocytic differentiation via the activation of IDO. A functional KP present in MSCs, NSCs and perhaps other stem cell types offers novel therapeutic opportunities for optimisation of stem cell proliferation and differentiation.
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