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Fang Chen et al.
BIOCHEMICAL PHARMACOLOGY (2010)
mRNA display selection of a high-affinity, Bcl-XL-specific binding peptide
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FASEB JOURNAL (2010)
Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
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Mark Wade et al.
TRENDS IN CELL BIOLOGY (2010)
Making Strides in Peptide-Based Therapeutics
Danielle A. Guarracino et al.
CHEMISTRY & BIOLOGY (2009)
Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
Joerg Kallen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Diverse backbone-cyclized peptides via codon reprogramming
Takashi Kawakami et al.
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Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
Marzena Pazgiera et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Awakening guardian angels: drugging the p53 pathway
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NATURE REVIEWS CANCER (2009)
Targeting the MDM2-p53 interaction for cancer therapy
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CLINICAL CANCER RESEARCH (2008)
Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer
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MOLECULAR CANCER THERAPEUTICS (2008)
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
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NATURE REVIEWS CANCER (2006)
Determinants of specificity of MDM2 for the activation domains of p53 and p65: Proline27 disrupts the MDM2-binding motif of p53
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BIOCHEMISTRY (2006)
A highly flexible tRNA acylation method for non-natural potypeptide synthesis
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NATURE METHODS (2006)
In vitro evolution of proteins
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JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2006)
Current strategies for the development of peptide-based anti-cancer therapeutics
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
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JOURNAL OF MEDICINAL CHEMISTRY (2005)
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SCIENCE (2004)
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CHEMISTRY & BIOLOGY (2003)
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
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P53: An ubiquitous target of anticancer drugs
MV Blagosklonny
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Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
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