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Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
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Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells
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Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies
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TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases
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TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
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Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
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Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
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Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching
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Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
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Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation
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TDP-43, the signature protein of FTLD-U, is a neuronal activity-responsive factor
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Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
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cis-requirement for the maintenance of round spermatid-specific transcription
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TDP43 depletion rescues aberrant CFTR exon 9 skipping
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An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi
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Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene
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Structural diversity and functional implications of the eukaryotic TDP gene family
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GENOMICS (2004)
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Usefulness of double gene construct for rapid identification of transgenic mice exhibiting tissue-specific gene expression
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Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9
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