期刊
PLOS ONE
卷 5, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0013219
关键词
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资金
- National Institutes of Health [1R21AR055228-01A1]
- National Science Foundation [0606461]
- Chinese National Key Technologies RD Program [2006BAD04A01, 2006BAD01A10, 2008BADB2B03, 2008AA101010]
- National Department Public Benefit Research Foundation of China [nyhyzx07-035]
- National Natural Science Foundation of China [30871774]
- Waltham Center for Pet Nutrition
- Cornell Advanced Technology in Biotechnology
- Department of Clinical Sciences
- Baker Institute for Animal Health in the College of Veterinary Medicine, Cornell University
Background: Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA. Methodology/Principal Findings: A total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at similar to 22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with similar to 3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with hip OA. Conclusion/Significance: The identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and hip OA, which are common and debilitating conditions in both dogs and humans.
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